Quality control: UDP-glucose:glycoprotein glucosyltransferase (UGGT) works as the folding sensor in glycoprotein quality control. It glucosylates the Man9GlcNAc2 of misfolded glycoproteins to produce Glc1Man9GlcNAc2, which is a ligand of calnexin and calreticulin. The synthetic substrate Man9GlcNAc2-MTX can be used for the quantitative analysis of UGGT. UDP=uridine 5′-diphosphate, Glc=D-glucose, Man=D-mannose, GlcNAc=N-acetyl-D-glucosamine, MTX=methotrexate.
No takes yet. Share an insight, caveat, or question.
Totani et al. (2005) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: