Key result
Physical activity was associated with 145 validated bioactive lipids, of which 12 had opposite associations with incident cardiovascular disease events.
Why the study?
The mechanisms underlying physical activity-related cardioprotection remain unclear, prompting an examination of the association of physical activity with plasma bioactive lipids and cardiovascular disease events.
Does physical activity alter bioactive lipid profiles associated with incident cardiovascular events?
Observational
Does physical activity alter bioactive lipid profiles associated with incident cardiovascular events?
Physical activity is associated with specific bioactive lipid profiles, 12 of which are inversely associated with incident cardiovascular events, providing potential mechanistic insights into physical activity-related cardioprotection.
Answers are grounded in this paper and cite their sources.
May identify lipid mediators of exercise benefit; leaves open causal roles in CVD prevention.
BACKGROUND: To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations. METHODS: PA-bioactive lipid associations were examined in VITAL (VITamin D and OmegA-3 TriaL)-clinical translational science center (REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT01169259; N=1032) and validated in JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin)-NC (REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT00239681; N=589), using linear models adjusted for age, sex, race, low-density lipoprotein-cholesterol, total-C, and smoking. Significant BALs were carried over to examine associations with incident CVD in 2 nested CVD case-control studies: VITAL-CVD (741 case-control pairs) and JUPITER-CVD (415 case-control pairs; validation). RESULTS: We detected 145 PA-bioactive lipid validated associations (false discovery rate <0.1). Annotations were found for 6 of these BALs: 12,13-diHOME, 9,10-diHOME, lysoPC(15:0), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol. Genetic analysis within JUPITER-NC showed associations of 32 PA-related BALs with 22 single-nucleotide polymorphisms. From PA-related BALs, 12 are associated with CVD. CONCLUSIONS: We identified a PA-related bioactive lipidome profile out of which 12 BALs also had opposite associations with incident CVD events.
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Hoshi et al. (2022) conducted an observational in Cardiovascular disease. Physical activity was evaluated on Association of physical activity with plasma bioactive lipids and cardiovascular disease events (p=<0.1). Physical activity was associated with 145 validated bioactive lipids, of which 12 had opposite associations with incident cardiovascular disease events.
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