What question did this study set out to answer?

Develop a multi-step chemical synthesis strategy to construct tropane alkaloid ring systems, specifically targeting pseudotropine and racemic dl-cocaine.

April 1, 1979Journal of the American Chemical Society

Synthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaine

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Authors

JTJoseph J. TufarielloBuffalo State University GMG. B. MULLENKing's College London JTJohn J. TegelerHeinrich Heine University Düsseldorf

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Implication

Laboratory study demonstrates synthetic routes to tropane alkaloids in chemical precursors, highlighting novel pathways to assemble pseudotropine and dl-cocaine.

Key Points

Develop a multi-step chemical synthesis strategy to construct tropane alkaloid ring systems, specifically targeting pseudotropine and racemic dl-cocaine.
Employed organic chemical transformation sequences to construct the bicyclic nitrogen-containing tropane core.
Synthesized and characterized reaction intermediates leading to target tropane derivatives.
Successfully achieved the total chemical synthesis of pseudotropine.
Completed the stereoselective synthesis of dl-cocaine from intermediate tropane precursors.

Cite This Study

Tufariello et al. (1979) studied this question.

synapsesocial.com/papers/6a9c2a8542df18bb42c53c9c https://doi.org/10.1021/ja00503a033

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Implication

Laboratory study demonstrates synthetic routes to tropane alkaloids in chemical precursors, highlighting novel pathways to assemble pseudotropine and dl-cocaine.

Synthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaine

Discussion

Member takes

Implication

Key Points

Cite This Study

Synthesis in the tropane class of alkaloids. Pseudotropine and dl-cocaine

Discussion

Member takes

Implication

Key Points

Cite This Study

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