Key result
Antibiotic prophylaxis should be administered prior to surgery, tailored to the surgical type, host competence, and anticipated bacterial spectrum, and avoided if efficacy is doubtful.
Antibiotic prophylaxis should be used only in specific surgical settings, administered before the procedure, and tailored to cover anticipated organisms.
Selective prophylaxis curbs resistance without clear benefit in low-risk cases; leaves open need for procedure-specific RCTs.
Antibiotic prophylaxis is indicated only under specific surgical settings. Appropriate antibiotic prophylaxis must take into account the type of surgery, the competence of the host, and the pharmacologic properties of the antibiotic(s). The antibiotic should be given before the surgical procedure and have an antibacterial spectrum that covers the majority of the bacterial organisms anticipated at surgery. If there is doubt about the efficacy, antibiotic prophylaxis should not be initiated.
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Mader et al. (1984) conducted a review in Surgical settings requiring antibiotic prophylaxis. Preventive Antibiotics was evaluated. Antibiotic prophylaxis should be administered prior to surgery, tailored to the surgical type, host competence, and anticipated bacterial spectrum, and avoided if efficacy is doubtful.
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