Key result
Post-traumatic growth independently mediated the association between family caregiver burden and medication adherence in patients with mechanical valve replacement (β = 0.32; 95% CI -0.016 to -0.008).
Why the study?
Although family caregiver burden negatively correlates with medication adherence after mechanical valve replacement, little is known about the underlying mechanism.
Cross-Sectional (n=206)
Effect estimate: β = 0.32 (95% CI -0.016, -0.008)
p-value: p=< 0.05
In patients with mechanical valve replacement, post-traumatic growth mediates the negative impact of family caregiver burden on medication adherence.
May support targeting post-traumatic growth to ease caregiver burden effects on adherence; hypothesis-generating and requires prospective confirmation before practice change.
Background: Oral anticoagulant is a necessary long-term treatment after mechanical valve replacement (MVR), and medication adherence has a great impact on patients with MVR. Although family caregiver burden is negatively correlated with medication adherence, little is known about the underlying mechanism. Purpose: To test whether family caregiver burden influences medication adherence through post-traumatic growth or medication literacy in patients with MVR. Patients and Methods: A total of 206 patients after MVR were included in this cross-sectional study from July 2021 to December 2021. Data regarding medication adherence, family caregiver burden, post-traumatic growth, and medication literacy were collected by questionnaires. Data were analyzed through SPSS, and pathway analysis was conducted by using AMOS, based on the bootstrapping method. Results: < 0.05). Post-traumatic growth independently mediated the association of family caregiver burden on medication adherence [β = 0.32, 95% confidence intervals: (-0.016, -0.008)]. The mediated effect value for post-traumatic growth was 0.07, accounting for 24.14% of the total effect. The model's fit indices were adequate. Conclusion: The mediating effect of post-traumatic growth between family caregiver burden and medication adherence existed in patients with MVR. Interventions considering post-traumatic growth may be useful to increase medication adherence and improve patient rehabilitation.
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Liu et al. (2022) conducted a cross-sectional in Mechanical valve replacement (MVR) (n=206). Family caregiver burden was evaluated on Medication adherence (β = 0.32, 95% CI -0.016, -0.008, p=< 0.05). Post-traumatic growth independently mediated the association between family caregiver burden and medication adherence in patients with mechanical valve replacement (β = 0.32; 95% CI -0.016 to -0.008).
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