Why the study?
Hypertension prevention strategies predominantly focus on treating individuals with established hypertension, but whether a coordinated community- and family-based intervention can shift the population distribution of systolic blood pressure remains uncertain.
Does a coordinated community- and family-based intervention reduce systolic blood pressure in adults aged 40 to 80 years in rural China?
Population
8,001 adults aged 40 to 80 years across 80 village clusters in rural China
Comparison
Multifaceted community- and family-based intervention vs usual care
Design
Cluster-randomized trial
Follow-up
12 months
Key result
A coordinated community- and family-based intervention significantly reduced systolic blood pressure compared to usual care at 6 months (adjusted difference -10.7 mm Hg; 95% CI -11.8 to -9.6).
Authors
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Most blood pressure programs focus on treatment for people with high blood pressure, whereas our study included the whole family regardless of their blood pressure levels. This approach could transform how we prevent heart disease in communities worldwide. By involving entire families and communities rather than treating individuals, we can likely reduce everyone's risk of heart attack and stroke, especially in areas where health care resources are limited.”
A multifaceted community- and family-based intervention significantly reduced systolic blood pressure at 6 months in a rural Chinese population, though the effect attenuated by 12 months.
RCT (n=8,001)
Blinded outcome assessment
Cluster-randomized (1:1)
Yes
Does a coordinated community- and family-based intervention reduce systolic blood pressure in adults aged 40 to 80 years in rural China?
Mean Difference: -10.7 (95% CI -11.8–-9.6)
Absolute Event Rate: -6% vs 5.1%
A multifaceted community- and family-based intervention significantly reduced systolic blood pressure at 6 months in a rural Chinese population, though the effect attenuated by 12 months.
Du et al. (2026) conducted an RCT in Blood pressure control (n=8,001). Coordinated community- and family-based intervention vs. Usual care was evaluated on Between-group difference in change in systolic blood pressure from baseline to 6 months (MD -10.7 mm Hg, 95% CI -11.8 to -9.6). A coordinated community- and family-based intervention significantly reduced systolic blood pressure compared to usual care at 6 months (adjusted difference -10.7 mm Hg; 95% CI -11.8 to -9.6).
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