Serum concentrations of argininosuccinate lyase were determined in 122 patients with primary and secondary diseases of the liver. For comparison, patients with diseases involving other organs of the body were also studied. Extent of liver damage was evaluated by liver biopsy and in some cases, were assessed at autopsy. Daily assays, made during the course of the hospital stay, were correlated with blood concentrations of SGOT, SGPT, LDH, CPK, alkaline phosphatase, bilirubin, total and free cholesterol, and with the thymol turbidity and cephalin flocculation tests, and the albumin to globulin ratio. We tentatively conclude that, compared with these other commonly used tests of liver function, measurement of ASAL is a more specific and sensitive test for disease of the liver parenchyma. The procedure is simple and is readily made routine.
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Campanini et al. (1970) studied this question.
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