Why the study?
Spain still prescribes acenocoumarol and restricts primary care physicians from prescribing other anticoagulants that are more effective and less bothersome than digital INR testing.
Does close monitoring and management of drug/food interactions improve INR lability in patients with non-valvular atrial fibrillation taking acenocoumarol?
Observational (n=250)
Yes
Does close monitoring and management of drug/food interactions improve INR lability in patients with non-valvular atrial fibrillation taking acenocoumarol?
Close monitoring of INR and management of interactions with food and drugs like omeprazole significantly reduces INR lability in patients taking acenocoumarol for non-valvular atrial fibrillation.
Supports weekly INR monitoring to stabilize acenocoumarol; hypothesis-generating and requires randomized confirmation before practice change.
Spain is one of the few countries in Europe that still prescribes Acenocoumarol, similar to warfarin. So much so that primary care physicians are not allowed to prescribe other anticoagulants that are more effective and less bothersome for the patient when taking the digital INR test. The study was performed in a primary care health system and secondary category hospitals. We were setting in a population of 250 inhabitants in southeastern Spain (Number of patients to be treated is sufficient) with non-valvular atrial fibrillation and Acenocoumarol takers. The follow-up time was 12 months.
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FR Breijo-Marquez (2022) conducted an observational in Non-valvular atrial fibrillation (n=250). Weekly INR monitoring and medication management was evaluated on Disappearance of INR lability for more than three months.
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