Amiodarone and Torsade de Pointes

Letters1 April 1995Amiodarone and Torsade de PointesTsung O. ChengTsung O. ChengSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-7-199504010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:No sooner had I finished reading the convincing review by Hohnloser and associates [1], who argued against the importance of amiodarone-associated proarrhythmic effects, than I read an equally persuasive article expressing a diametrically opposed view in another journal published at the same time [2]. The former article [1] concluded that the “low arrhythmogenicity and the negligible negative inotropic effect. make amiodarone particularly useful in treating high-risk patients (with coronary artery disease) prone to sudden cardiac death (due to torsade de pointes tachycardia),” whereas the latter concluded that “amiodarone therapy should be withheld in patients with ventricular tachycardia ...References1. Hohnloser SH, Klingenheben T, Singh BN. Amiodarone-associated proarrhythmic effects. A review with special reference to torasade de pointes tachycardia. Ann Intern Med. 1994; 121:529-35. Google Scholar2. Mickleborough LL, Maruyama H, Mohamed S, Rappaport DC, Downar E, Butany J, et al. Are patients receiving amiodarone at increased risk for cardiac operations? Ann Thorac Surg. 1994; 58:622-9. Google Scholar3. Cheng TO. Acronyms of clinical trials in cardiology—1994. Am J Cardiol. 1994; 74:79-94. Google Scholar Author, Article, and Disclosure InformationAuthors: Tsung O. Cheng PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1995Volume 122, Issue 7 Page: 553-554 Keywords Atrial fibrillation Health care Heart failure Mortality Myocardial infarction Patients Stable coronary artery disease Sudden cardiac death Tachycardia Ventricular tachycardia ePublished: 15 August 2000 Issue Published: 1 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...