Low-energy synchronous cardioversion of ventricular tachycardia using a catheter electrode in a canine model of subacute myocardial infarction.
Key result
Transvenous, intracardiac, R-wave-synchronous shocks of 0.008-1.0 J safely terminated 83% (25 of 30) of sustained ventricular tachycardias with cycle lengths > 200 msec in a canine model.
Why the study?
Does low-energy synchronous cardioversion using a catheter electrode terminate sustained ventricular tachycardia in a canine model of subacute myocardial infarction?
Population
24 surviving adult mongrel dogs with subacute myocardial infarction, 14 of which had 627 episodes of induced…
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for low-energy intracardiac VT cardioversion in infarct models; leaves open translation to human therapy.
Structured PICO
Does low-energy synchronous cardioversion using a catheter electrode terminate sustained ventricular tachycardia in a canine model of subacute myocardial infarction?
P
Population
24 adult mongrel dogs with subacute myocardial infarction undergoing programmed electrical stimulation to induce sustained ventricular tachycardia.
I
Intervention
Low-energy (0.008-1.0 J, median 0.5 J) synchronized truncated exponential shocks delivered through transvenous, intracardiac catheter electrodes (right ventricular apex to superior vena cava).
O
Outcome
Termination of sustained ventricular tachycardia
Low-energy transvenous synchronized shocks safely and effectively terminate sustained ventricular tachycardia with cycle lengths >200 msec in a canine model of subacute myocardial infarction.
Cite This Study
Jackman et al. (1982) studied Ventricular tachycardia in subacute myocardial infarction (n=24). Low-energy, synchronized shocks via transvenous, intracardiac catheter electrodes was evaluated on Termination of sustained ventricular tachycardia with cycle length > 200 msec. Transvenous, intracardiac, R-wave-synchronous shocks of 0.008-1.0 J safely terminated 83% (25 of 30) of sustained ventricular tachycardias with cycle lengths > 200 msec in a canine model.