Key result
Recent developments have improved the assessment of platelet-VWF interactions and expanded therapeutic approaches for patients with disorders of VWF function.
This review highlights the complex interactions between platelets, von Willebrand factor, and the vascular endothelium, as well as therapeutic approaches for VWF disorders.
May inform assessment of VWF disorders; leaves open need for prospective trials before practice change.
The complex interactions of platelets, von Willebrand factor (VWF), and vascular endothelium have been explored by many investigators during the last decade. With the development of better methods to assess these components has come an increased recognition of diseases associated with defects in the platelet-VWF interaction. Moreover, alternative therapeutic approaches have become available for the clinician who treats patients with disorders of VWF function.
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Moroose et al. (1986) conducted a review in Disorders of von Willebrand factor (VWF) function. Recent developments have improved the assessment of platelet-VWF interactions and expanded therapeutic approaches for patients with disorders of VWF function.
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