Key result
The Puf repeat domain of Puf3p binds to two specific UGUANAUA sites in the 3' UTR of COX17 mRNA, which is sufficient to stimulate rapid mRNA decay in yeast.
The study identifies specific binding sites and domains required for Puf3p-mediated mRNA decay in yeast, advancing understanding of post-transcriptional gene regulation.
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Hypothesis-generating in yeast; leaves open any role for Puf proteins in human cardiovascular mRNA regulation.
Jackson et al. (2004) studied this question. Puf3p binding to COX17 mRNA 3' UTR was evaluated on COX17 mRNA decay regulation. The Puf repeat domain of Puf3p binds to two specific UGUANAUA sites in the 3' UTR of COX17 mRNA, which is sufficient to stimulate rapid mRNA decay in yeast.
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