Key result
Women had a significantly higher prevalence of tricuspid regurgitation compared to men (18.5% vs 16.7%), whereas aortic regurgitation was more prevalent in men (14.9% vs 5.5%).
Why the study?
Prevalence of different valvular pathologies had not been reported in female and male patients in large population-based studies.
Observational (n=24,265)
No
Absolute Event Rate: 18.5% vs 16.7%
p-value: p=<0.001
This large retrospective echocardiographic study demonstrates significant gender differences in valvular heart disease, with aortic regurgitation being more prevalent in men and tricuspid regurgitation more prevalent in women.
Sex differences in TR/AR prevalence should not yet change practice; leaves open need for prospective validation of clinical relevance.
INTRODUCTION: Prevalence of different valvular pathologies has not been reported in female and male patients in large population-based studies. The goal of this study was to report the gender-specific prevalence of various valvular pathologies. METHODS: We retrospectively analyzed 24,265 echocardiograms performed between 1984 and 1998. The prevalence of mitral regurgitation (MR) aortic valve regurgitation (AR) and stenosis (AS), and tricuspid regurgitation (TR) were calculated in female and male patients. RESULTS: Echocardiograms were performed on 12,926 (53%) female and 11,339 (47%) male patients. Gender-specific echocardiographic prevalence of different valvular abnormalities was as follows: Prevalence of mitral regurgitations was similar in women and men (25% vs 24.7%). Aortic regurgitation was higher in males (5.5 vs 14.9%, P < 0.001). Aortic stenosis prevalence was similar between both genders (2.1 vs 2.3%). Tricuspid valve regurgitations were slightly higher in females (18.5 vs 16.7%, P < 0.001). CONCLUSION: In this study, we found a significantly higher prevalence of tricuspid valve regurgitation in women. Aortic regurgitation was more prevalent in men. Aortic stenosis and mitral regurgitation had similar prevalence in both genders.
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Mohammad Reza Movahed (2025) conducted an observational in Valvular heart disease (n=24,265). Female sex vs. Male sex was evaluated on Prevalence of tricuspid regurgitation (p=<0.001). Women had a significantly higher prevalence of tricuspid regurgitation compared to men (18.5% vs 16.7%), whereas aortic regurgitation was more prevalent in men (14.9% vs 5.5%).
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