Key result
Nuclear clusterin (nCLU) plays a pro-apoptotic role in the brain by interacting with Bcl-XL through a putative BH3 domain, contributing to brain damage and neurodegeneration.
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This review summarizes the pro-apoptotic function of nuclear clusterin in brain damage and neurodegeneration.
Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.
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Kim et al. (2011) conducted a review in Brain damage and neurodegeneration. Nuclear clusterin (nCLU) was evaluated. Nuclear clusterin (nCLU) plays a pro-apoptotic role in the brain by interacting with Bcl-XL through a putative BH3 domain, contributing to brain damage and neurodegeneration.
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