ulin (a putative megalin ligand) was also detected in this patient, but immunohistochemical analyses revealed no apparent change in its uptake (Fig. S4E and S4F in the Supplementary Appendix), which suggested β 2 -microblobin is also a shared ligand.Consequently, we tested the binding capacity of α 1 -microglobulin to cubilin (with the use of surface-plasmon-resonance analyses, as described in the Supplementary Appendix and shown in Fig. S3B) and found that α 1 -microglobulin is also a cubilin ligand.Studies in rodents have shown that both cubilin and amnionless are essential to normal embryonic development.However, no lethal phenotype or malformations were observed in the dogs deficient in amnionless in the above-mentioned model.Since our patient has no additional apparent developmental abnormalities or physical disabilities, it appears that cubilin is not essential for human embryonic development.Furthermore, the functional immunohistochemical analyses of specimens from this patient's kidney indicate that cubilin and amnionless also have an interdependent relationship in humans.
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Cox et al. (2011) studied this question.