Key result
ATP and inorganic orthophosphate stabilize actin filaments against breakdown, achieving maximal ATP stabilization when only about 15% of actin subunits bind a nucleotide molecule.
ATP and inorganic orthophosphate stabilize actin filaments, with maximal stabilization occurring when only ~15% of actin subunits have bound a nucleotide molecule.
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Does not inform clinical practice; leaves open nucleotide effects on actin dynamics in cardiovascular models.
Both inorganic orthophosphate and ATP stabilize actin filaments. This is reflected by a reduced nucleotide exchange and by a protection against filament breakdown by SDS or KI. When the filament-stabilizing effect of ATP was maximal, only about 15% of the actin subunits of the filament had bound one molecule of the nucleotide offered in the stabilizing solution.
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Dancker et al. (1989) studied this question. ATP and inorganic orthophosphate stabilize actin filaments against breakdown, achieving maximal ATP stabilization when only about 15% of actin subunits bind a nucleotide molecule.
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