Santonin, a natural product, was aromatized with molecular iodine as the catalyst. The new compound was characterized as ( S )-methyl-2-(7-hydroxy-5,8-dimethylnaphthalen-2-yl) propanoate ( 2 ) based on 2D NMR spectroscopic data. Structurally, compound 2 was highly similar to the anti-inflammatory drug naproxen. The new naproxen analogue had significant potency against cyclooxygenase 1 and 2 (IC 50 = 31.0 and 66.1 μM, respectively).
No takes yet. Share an insight, caveat, or question.
Singh et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: