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Review highlights crosstalk between macropinocytosis and autophagy in nutrient-depleted cancer cells, suggesting coordinated scavenging networks sustain tumor survival under starvation.
Adaptive strategies used by cells to scavenge and recycle essential nutrients are important for survival in nutrient-depleted environments such as cancer tissues. Autophagy and macropinocytosis are two major mechanisms that promote nutrient recycling and scavenging, which share considerable, yet poorly understood, cross-regulation. Here we review recent findings that connect these starvation response mechanisms and discuss the implications of their crosstalk. This article is part of the Theo Murphy meeting issue 'Macropinocytosis'.
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Florey et al. (2018) studied this question.
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