Key result
Uncontrolled hypertension linked to ~5-point lower cognitive scores versus controlled hypertension in older adults.
Why the study?
Hypertension is a potentially modifiable risk factor for cognitive decline, and understanding which hypertension variables relate to cognitive functions may help mitigate this risk.
Does hypertension status and duration affect cognitive functions in older adults?
Cross-Sectional (n=95)
No
Does hypertension status and duration affect cognitive functions in older adults?
Absolute Event Rate: 76.2% vs 81.5%
p-value: p=0.04
Uncontrolled hypertension and shorter duration of hypertension are associated with poorer cognitive functions, particularly in attention and fluency domains, in older adults.
Uncontrolled hypertension may link to lower cognition in older adults; extends observational data but leaves open causality and practice change.
Background Hypertension is a potentially modifiable risk factor for cognitive decline. Understanding the variables of hypertension related to cognitive functions will help in mitigating the risk. Objective The study aims to assess the characteristics of hypertension and its effect on cognitive functions in the older adults. Methods The study involved 95 hypertensive participants aged 60 years and above from cardiology and medicine outpatient services of a tertiary care hospital from August to October 2022. The characteristics of hypertension and cognitive functions were assessed using semi-structured proforma and Adenbrooke's Cognitive Examination (ACE-III) Hindi version respectively. Further, individual cognitive functions were compared with duration of the hypertension and hypertensive status of the participants. The chi-square test and independent t-tests were used and p value < 0.05 was considered to be significant. Result The mean age of the study population was 68.2 years, the cognitive functions was comparable in terms of age, sex, locality, co-morbidity, and treatment characteristic. Although a significant difference in cognitive functions was present in relation to duration and status of hypertension. Among the individual cognitive domains, a significant difference was observed in attention and fluency domains of cognitive function based on HTN status (p > 0.05) but differential effect on cognitive domains was not seen with the duration of HTN. However, there was overall decline in cognitive domains with both hypertension status and the duration of hypertension. Conclusion The study highlights association of status of hypertension and its characteristics with cognitive decline.
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Parandiyal et al. (2024) conducted a cross-sectional in Hypertension (n=95). Uncontrolled hypertension vs. Controlled hypertension was evaluated on Overall cognitive function (ACE-III score) (p=0.04). Uncontrolled hypertension was associated with significantly lower overall cognitive function scores compared to controlled hypertension (76.2 vs 81.5, p=0.04) in older adults.
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