July 6, 2010Journal of Cardiovascular Medicine
Predictive value of cardiac troponin-I compared to creatine kinase-myocardial band for the assessment of infarct size as measured by cardiac magnetic resonance
Key result
Cardiac troponin I assessed at 72 hours from symptom onset accurately estimated predischarge infarct volume (r=0.84; 95% CI 0.75-0.91), significantly outperforming creatine kinase-myocardial band.
Why the study?
Does cardiac troponin I (cTnI) measurement at 72 hours from symptom onset improve the estimation of predischarge infarct volume compared to CK-MB in patients with a first acute myocardial infarction?
Population
60 patients with a first acute myocardial infarction and normal function. 52 STEMI patients underwent…
Comparison
Cardiac troponin I measurement at 72 hours from… vs Creatine kinase-myocardial band measurement and…
Design
Cohort
Follow-up
predischarge (4 +/- 2 days)
Authors
Discussion
Loading...
Member takes
Implication
May support 72-hour cTnI for post-MI infarct sizing; hypothesis-generating and should not yet change practice.
Study Design
Type
Observational (n=60)
Structured PICO
Does cardiac troponin I (cTnI) measurement at 72 hours from symptom onset improve the estimation of predischarge infarct volume compared to CK-MB in patients with a first acute myocardial infarction?
P
Population
60 patients with a first acute myocardial infarction (STEMI and NSTEMI) and normal function, evaluated for infarct volume by DE-CMR before discharge.
E
Exposure
Cardiac troponin I (cTnI) measurement at 72 hours from symptom onset
C
Comparator
Creatine kinase-myocardial band (CK-MB) measurement and peak/total cTnI values
O
Outcome
Correlation with predischarge infarct volume as assessed by delayed-enhancement cardiac magnetic resonance (DE-CMR)surrogate
Main Result
Effect estimate: r = 0.84 (95% CI 0.75-0.91)
p-value: p=< 0.002
A single cTnI measurement at 72 hours post-symptom onset accurately estimates infarct size in patients with a first acute myocardial infarction, outperforming CK-MB and peak cTnI values.
Cite This Study
Chiara et al. (2010) conducted an observational in Acute myocardial infarction (STEMI and NSTEMI) (n=60). Cardiac troponin I (cTnI) assessment at 72 hours vs. Creatine kinase-myocardial band (CK-MB) assessment was evaluated on Predischarge infarct volume as assessed by DE-CMR (r = 0.84, 95% CI 0.75-0.91, p=< 0.002). Cardiac troponin I assessed at 72 hours from symptom onset accurately estimated predischarge infarct volume (r=0.84; 95% CI 0.75-0.91), significantly outperforming creatine kinase-myocardial band.