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The monomeric unit of the macrodiolide SCH 351448 has been synthesized from three building blocks. Strategic disconnections were chosen between C21–C22 (Wittig) and C10–C11 (stereoselective aldol). The cis configuration of both 2,6‐disubstituted tetrahydropyran rings was established by a stereoselective cationic reduction. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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Backes et al. (2006) studied this question.
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