Key result
RDN lowers BP or medication use in ~88% of resistant hypertension patients over long-term follow-up.
Why the study?
The long-term outcomes of renal denervation for resistant hypertension needed to be determined.
Does percutaneous renal nerve denervation improve blood pressure control or reduce medication burden in patients with resistant hypertension?
Observational (n=17)
No
Does percutaneous renal nerve denervation improve blood pressure control or reduce medication burden in patients with resistant hypertension?
Renal nerve denervation provided sustained blood pressure reduction and/or reduced medication burden in over 80% of Thai patients with resistant hypertension over a long-term follow-up of up to 9 years.
Supports potential long-term benefit of renal denervation; hypothesis-generating from Level 5 evidence and should not change practice.
We aimed to determine the long-term outcome of renal denervation (RDN). All patients with resistant hypertension who underwent RDN between 2012 and 2018 at Siriraj Hospital were included in the study. Patients were followed up at 3, 6, and 12 months and then annually up to 9 years. Effectiveness of the RDN outcome was defined by either (1) a reduction in office systolic BP ≥ 10 mmHg, (2) a reduction in the number of antihypertensive drugs taken, or (3) both outcomes being achieved. In total, 18 RDN procedures were performed during the study period. The mean and longest follow-up periods were 52 months and 104 months, respectively. Heterogeneous BP responses after RDN for resistant hypertension were observed. Effectiveness of the RDN outcome was achieved in 88% of the patients at 1 year and in >80% of the patients during the entire follow-up at each time point up to 9 years.
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Wanthong et al. (2022) conducted an observational in Resistant hypertension (n=17). Renal nerve denervation was evaluated on Effectiveness of RDN (reduction in office systolic BP ≥ 10 mmHg and/or reduction in antihypertensive drugs). Renal nerve denervation achieved effective outcomes (systolic blood pressure reduction ≥10 mmHg or reduced medications) in over 80% of patients with resistant hypertension for up to 9 years.
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