Key result
Among 23 patients with end-stage renal disease on hemodialysis, mitral annular calcification was present in 39% and significant coronary artery disease in 30%.
Why the study?
Does the presence of mitral annular calcification predict coronary artery disease in end-stage renal disease patients on hemodialysis?
Observational (n=23)
Does the presence of mitral annular calcification predict coronary artery disease in end-stage renal disease patients on hemodialysis?
In patients with end-stage renal disease on hemodialysis, the presence of mitral annular calcification is a predictor of significant coronary artery disease.
Answers are grounded in this paper and cite their sources.
May indicate coronary risk in hemodialysis; hypothesis-generating and requires larger prospective validation before practice change.
BackgroundMitral annulus calcifi cation ( MAC) is a chronic, degenerative process of the fi brous support structure of the mitral valve. The reported prevalence of MAC is between 8 and 15%, but it signifi cantly increases with age and in patients with multiple cardiovascular risk factors or chronic kidney disease. AimThe aim of this study was to determine whether MAC predicts coronary artery disease in a group of end-stage renal disease patients.Patients and MethodsTwenty-three patients with ESRD on hemodialysis referred for coronary angiography were prospectively studied.ResultsThis study included 23 patients, MAC was seen in nine patients (39%). Seven patients had significant coronary artery disease (CAD) (30%). Ten patients had impaired left ventricular function (LVEF <50%) but none had severe impairment (LVEF <30%).ConclusionMAC occurs in a proportion of patients with ESRD and is associated with increased mortality and the presence of significant CAD.
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AmirS Michael (2018) conducted an observational in End-stage renal disease on hemodialysis (n=23). Mitral annular calcification was evaluated on Significant coronary artery disease. Among 23 patients with end-stage renal disease on hemodialysis, mitral annular calcification was present in 39% and significant coronary artery disease in 30%.
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