An Electron Microscopy of the Renal Differentiation

1) The author has observed by electron microscope the glomerular differentiation of rats.2) Glomerular capillary is formed by the glomerular anlage cells which appear beneath the inner layer of the metanephrogenic vesicle.3) Glomerular anlage cells proliferate immediately below the inner layer and form intercellular space and later on blood' cavities. From a very early stage these intercellular spaces or blood cavities have communication with sinusoids which exist in the renal cortex.4) Basement membrane appears between the inner layer and glomerular anlage cells. The anlage cells further proliferate and successively produce new blood cavities in continuation with the first blood cavity immediately under the basement membrane.5) As glomerulus develops the glomerular pattern grows more complicated but the arrangement of the components that compose the cavity walls remain unchanged from the early stages of immature gromerulus to maturity.6) The differentiation of the glomerular structural components i.e., epithelial cells, basement membrane, endothelial cells and mesangium has been treated on.The author would like to express his grateful appreciation to Prof. T. Kobayashi. The author also is indebted to Dr. H. Sakaguchi for his help and advice.