Key result
Initiation of capecitabine in a 70-year-old man with metastatic colon cancer induced coronary vasospasm, representing the first reported occurrence with this drug.
Case Report (n=1)
This is the first reported case of coronary vasospasm associated with the use of capecitabine.
May prompt vasospasm monitoring with capecitabine; first case leaves open incidence and causality.
The authors report the case of a 70-year-old man with metastatic colon cancer and no known history of coronary disease or major risk factors who developed coronary vasospasm after the initiation of capecitabine (Xeloda). Although coronary vasospasm has been associated with another older fluoropyrimidine compound, 5-fluorouracil, this is the first reported occurrence with this relatively newer cancer drug.
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Rizvi et al. (2004) conducted a case report in Metastatic colon cancer (n=1). Capecitabine was evaluated on Coronary vasospasm. Initiation of capecitabine in a 70-year-old man with metastatic colon cancer induced coronary vasospasm, representing the first reported occurrence with this drug.
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