Key result
Mitral valvuloplasty cuts operative mortality ~63% vs MVR in active native mitral infective endocarditis.
Why the study?
Does mitral valvuloplasty improve survival compared to mitral valve replacement in patients with active native mitral infective endocarditis?
Population
633 patients with active native mitral infective endocarditis pooled from 9 comparative observational studies
Comparison
Mitral valvuloplasty (MVP) / mitral valve repair vs Mitral valve replacement (MVR)
Design
Meta-analysis
Follow-up
1 and 5 years
Authors
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Supports preferring mitral valvuloplasty over replacement when feasible in active native mitral IE; extends meta-analytic evidence for lower operative mortality.
Meta-Analysis (n=633)
Does mitral valvuloplasty improve survival compared to mitral valve replacement in patients with active native mitral infective endocarditis?
Odds Ratio: 0.37 (95% CI 0.18–0.8)
p-value: p=0.0005
In patients with active native mitral infective endocarditis, mitral valve repair is associated with lower operative mortality and better long-term survival compared to valve replacement.
Liu et al. (2017) conducted a meta-analysis in Active native mitral infective endocarditis (n=633). Mitral valvuloplasty (MVP) vs. Mitral valve replacement (MVR) was evaluated on Operative mortality (OR 0.37, 95% CI 0.18-0.80, p=0.0005). Mitral valvuloplasty significantly reduced operative mortality compared to mitral valve replacement (OR 0.37; 95% CI 0.18-0.80; p=0.0005) in active native mitral infective endocarditis.
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