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THE prevalence of essential hypertension, its crippling potentialities and its threat to life make it one of the greatest of clinical problems. The complexities are all the greater because a combination of influences, rather than a single factor, produces the phenomenon. Adrenocortical function and its influence on sodium metabolism and renal function, the kidneys and the secondary part that they play in retaining sodium in this disease, the pressor substances elaborated in the kidneys and elsewhere and the effect that central stimulation exerts on these processes are among the considerations in its management. It is not surprising in view of . . .
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Duncan et al. (1953) studied this question.
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