Key result
PAR-1 and PAR-4 stimulation triggers highly correlated alpha-granule protein release, arguing against differential release.
Effect estimate: Spearman's r 0.94
p-value: p=< 0.001
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No immediate clinical implications; challenges differential alpha-granule release and leaves open in vivo relevance.
Holten et al. (2014) studied this question. PAR-1 stimulation vs. PAR-4 stimulation was evaluated on Correlation of released proteins (Spearman's r 0.94, p=< 0.001). PAR-1 and PAR-4 stimulation of platelets resulted in highly correlated release profiles of alpha-granule proteins (Spearman's r 0.94, P < 0.001), providing evidence against differential release.
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