Key result
Treatment with lorazepam 2 mg IV every 8 hours led to dramatic symptom improvement within 24 hours in a patient with catatonia, allowing for discharge after 1 week.
Case Report (n=1)
Lorazepam was effective in rapidly reversing catatonia symptoms in an ICU patient.
Hypothesis-generating for lorazepam in ICU catatonia; prospective trials needed before practice change.
Immediately post IV midazolam, we noticed that the patient's symptoms improved dramatically with regard to mobility and speech.His symptoms reappeared within 30 minutes after a brief period of improvement.That was when an alternate diagnosis of catatonia was contemplated and after a psychiatric opinion, the patient was started on lorazepam 2 mg IV every 8 hours.CSF analysis and cultures were negative for bacterial/viral meningoencephalitis.His symptoms improved within 24 hours.He was discharged after 1 week with tapering doses of lorazepam and to be followed up after 1 week by a psychiatrist/physician (Table 1).
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Kumar et al. (2023) conducted a case report in Catatonia (n=1). Lorazepam was evaluated on Symptom improvement. Treatment with lorazepam 2 mg IV every 8 hours led to dramatic symptom improvement within 24 hours in a patient with catatonia, allowing for discharge after 1 week.
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