Key result
Conservative medical management of intracranial carotid artery atherosclerosis frequently fails, with studies showing annual mortality rates ranging from 4.7% to 17.2% and ipsilateral stroke rates from 3.1% to 7.6%.
Why the study?
Does maximal medical therapy prevent stroke and death in patients with intracranial carotid artery atherosclerosis?
Does maximal medical therapy prevent stroke and death in patients with intracranial carotid artery atherosclerosis?
Patients with intracranial carotid artery atherosclerosis remain at high risk for stroke and death despite maximal medical therapy, highlighting the potential need for alternative treatments such as endovascular procedures.
Intracranial atherosclerosis is the cause of a significant number of strokes. Despite maximal medical therapy, this disease continues to carry a poor prognosis. The authors reviewed studies in which the outcomes after conservative management in patients with intracranial carotid artery atherosclerosis were reported. Analysis of the literature demonstrates that maximal medical therapy frequently fails with this disease, leaving patients at high risk for cerebral infarction and death. A better understanding of the pathophysiological aspects and natural history of this condition may serve to guide clinical decision making and the choice of therapeutic options in this patient population.
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Komotar et al. (2005) conducted a review in Intracranial carotid artery atherosclerosis. Conservative medical management was evaluated on Annual ipsilateral stroke and mortality rates. Conservative medical management of intracranial carotid artery atherosclerosis frequently fails, with studies showing annual mortality rates ranging from 4.7% to 17.2% and ipsilateral stroke rates from 3.1% to 7.6%.
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