Key result
Incident cardiovascular disease was associated with higher odds of physical and cognitive impairment, with the highest risk in patients aged ≥85 years (aOR 3.01; 95% CI 2.40-3.77).
Why the study?
Although cardiovascular disease is known to increase cognitive and physical impairment risk, the magnitude of this risk among relevant CVD subtypes or age cohorts remains poorly understood.
Does incident cardiovascular disease increase the risk of physical and cognitive impairment in adults aged ≥65 years?
Population
16 679 U.S. Health and Retirement Study participants aged ≥65 years at study entry
Comparison
Incident CVD vs CVD free
Design
Longitudinal cohort study
Follow-up
Median of 10 years
Authors
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May inform post-CVD monitoring in adults ≥85; extends associations but remains hypothesis-generating.
Cohort (n=16,679)
Does incident cardiovascular disease increase the risk of physical and cognitive impairment in adults aged ≥65 years?
Odds Ratio: 3.01 (95% CI 2.4–3.77)
Incident cardiovascular disease, particularly stroke, significantly increases the risk of both physical and cognitive impairment in older adults, with the highest risk observed in those aged 85 and older.
Stone et al. (2023) conducted a cohort in Incident cardiovascular disease (n=16,679). Incident cardiovascular disease vs. CVD free was evaluated on Physical impairment (activities of daily living impairment) or cognitive impairment (Langa-Weir Classification of dementia) (aOR 3.01, 95% CI 2.40-3.77). Incident cardiovascular disease was associated with higher odds of physical and cognitive impairment, with the highest risk in patients aged ≥85 years (aOR 3.01; 95% CI 2.40-3.77).
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