Why the study?
Does the combination of clopidogrel and aspirin prevent vascular events better than clopidogrel alone in high-risk ischemic cerebrovascular patients?
RCT
Does the combination of clopidogrel and aspirin prevent vascular events better than clopidogrel alone in high-risk ischemic cerebrovascular patients?
Answers are grounded in this paper and cite their sources.
The combination of clopidogrel and aspirin does not provide a net benefit over clopidogrel alone for secondary stroke prevention due to an increased risk of bleeding.
Antiplatelet drugs have an established efficacy in the secondary prevention of ischemic stroke. The recent results of the CAPRIE, CURE, and CREDO studies formed the rationale for the MATCH, designed to test whether the association of clopidogrel and aspirin was better than clopidogrel alone for the prevention of vascular events among high-risk ischemic cerebrovascular patients. Although the benefits were outweighed for a higher bleeding risk in the combination group, this study will provide important insight for upcoming trials in other to determine what populations might mostly benefit from these drugs for the secondary prevention of stroke in the future.
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Bezerra et al. (2005) conducted an RCT in Ischemic stroke. Clopidogrel and aspirin vs. Clopidogrel alone was evaluated on Vascular events.
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