Key result
Adding dexamethasone to intrathecal bupivacaine delays first analgesic request by ~94 minutes in cesarean sections.
Why the study?
Optimal anesthesia requires rapid onset with minimal hemodynamic changes and side effects, prompting evaluation of concomitant dexamethasone and bupivacaine on anesthesia duration and quality during cesarean section.
Does adding intrathecal dexamethasone to bupivacaine improve the duration and quality of spinal anesthesia in pregnant women undergoing cesarean section?
RCT (n=70)
Double-blind
Block method
No
Does adding intrathecal dexamethasone to bupivacaine improve the duration and quality of spinal anesthesia in pregnant women undergoing cesarean section?
Absolute Event Rate: 345.83% vs 251.52%
p-value: p=0.0001
Adding intrathecal dexamethasone to bupivacaine for spinal anesthesia during cesarean section significantly prolongs analgesia and reduces postoperative pain.
Supports intrathecal dexamethasone adjunct for extended post-cesarean analgesia; extends RCT evidence on spinal steroid adjuvants in obstetrics.
A perfect anesthesia technique is one in which anesthesia can be done in the shortest possible time with minimal hemodynamic changes and side effects This study is aimed to investigate the effects of concomitant administration of dexamethasone with bupivacaine on the duration of anesthesia and the quality of anesthesia-induced in patients undergoing cesarean section. This is a quasi-experimental study done on patients undergoing cesarean section by spinal anesthesia. All patients underwent standard monitoring after admission, then Ringer serum (5 cc/kg) was administered to the patients. The patients was then seated and subjected to intrathecal anesthesia with a midline approach in L3-L4 space. Patients were matched for baseline conditions. After recording background information, type and dosage of drugs used, blood pressure, heart rate, number and frequency of nausea and vomiting were listed in the checklist, and the data were analyzed using SPSS software. In this study, 70 pregnant women who were candidates for cesarean section were included. All our studied parameters, including the mean time to the start of analgesia, mean time of analgesia duration, analgesia duration, mean time to first request for analgesics were significantly improved among the intervention group. The use of dexamethasone and bupivacaine to induce spinal anesthesia during cesarean section can significantly shorten the onset time of analgesia and reduce postoperative nausea and vomiting. Dexamethasone can be used as an effective drug in cesarean section.
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Tabatabaei et al. (2022) conducted an RCT in Cesarean section (n=70). Dexamethasone and Bupivacaine vs. Bupivacaine 12.5 mg alone was evaluated on Mean time to first request for analgesics (minutes) (p=0.0001). Adding dexamethasone to intrathecal bupivacaine significantly prolonged the mean time to first request for analgesics compared to bupivacaine alone (345.83 vs 251.52 minutes) in patients undergoing cesarean section.
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