Key result
Heart transplantation for giant-cell myocarditis improved survival across 11 reviewed cases, with a recurrence rate of less than 50% that typically responded to intensive immunosuppression.
Why the study?
Does orthotopic cardiac transplantation improve survival in patients with idiopathic giant cell myocarditis?
Case Report (n=11)
Does orthotopic cardiac transplantation improve survival in patients with idiopathic giant cell myocarditis?
Heart transplantation is an excellent therapeutic option for idiopathic giant-cell myocarditis, offering improved survival despite a moderate, treatable risk of recurrence.
Answers are grounded in this paper and cite their sources.
May support transplantation consideration in giant-cell myocarditis; leaves open need for prospective data on recurrence.
We report the case of a 35-year-old woman suffering a rapidly progressive congestive heart failure. Echocardiogram and cardiac catheterization study showed a restrictive pattern with a ventricular ejection of 45%. Her clinical condition was dramatically deteriorated, and an urgent orthotopic cardiac transplantation was performed. Histological examination of the native explanted heart revealed an idiopathic giant-cell myocarditis. Posttransplant routine endomyocardial biopsies showed acute rejection but no evidence of recurrence. The patient's physical condition is good more than 14 months after transplantation. The outcome of the 11 cases of giant-cell myocarditis treated by heart transplantation, including the present, are reviewed. Heart transplantation is an excellent option for giant-cell myocarditis treatment since it improves survival. Recurrence rate is less than 50% and, when present, is usually responsive to intensive immunosuppression. Pretransplant endomyocardial biopsies are not always diagnostic of giant-cell myocarditis. Int J Surg Pathol 0(0):00-00, 1996
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Cabrera-Pozuelo et al. (1996) conducted a case report in Idiopathic giant-cell myocarditis (n=11). Heart transplantation was evaluated on Survival and recurrence. Heart transplantation for giant-cell myocarditis improved survival across 11 reviewed cases, with a recurrence rate of less than 50% that typically responded to intensive immunosuppression.
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