Key result
BP and renal function improve over 6 months after severe preeclampsia, though ~15% remain hypertensive.
Cohort (n=54)
No
In women with severe preeclampsia and eclampsia, hypertension and proteinuria frequently persist beyond the postpartum period, emphasizing the need for extended follow-up.
Answers are grounded in this paper and cite their sources.
Supports extended postpartum surveillance after severe preeclampsia; leaves open optimal duration and long-term outcome impact in observational data.
BACKGROUND: Preeclampsia and eclampsia, which are the most frequent hypertensive disorders in pregnancy, are associated with renal involvements. We aimed to assess the time trend in blood pressure levels, renal function and proteinuria after delivery, and investigate their determinants in Cameroonian women with severe preeclampsia and eclampsia. METHODS: This was a prospective cohort study involving 54 women with severe preeclampsia and eclampsia, conducted between July 2010 and February 2012 at the central maternity unit of the Yaoundé Central Hospital. Clinical and laboratory parameters were recorded from day-1 to 6 months after delivery. Mixed-linear and logistic regression models were used to relate baseline and within follow-up levels of covariates, with changes in blood pressure levels, renal function and proteinuria, as well as persisting hypertension, renal failure and proteinuria. RESULTS: During follow-up, a significant improvement was observed in blood pressure, renal function and proteinuria (all p < 0.002). Thirteen (24.1%) patients with renal failure at delivery recovered completely within six weeks. Twenty-six (48.1%), 17 (31.5%) and 1 (1.8%) patients had persisting proteinuria at 6 weeks, 3 months and 6 months post-delivery, respectively. Corresponding figures for persisting hypertension were 23 (42.6%), 15 (27.8%) and 8 (14.8%). Advanced age, higher body mass index, low gestational age at delivery, low fetal birth weight, and proteinuria at delivery were the main risk factors for persisting hypertension at 3 months, meanwhile low fetal birth weight, severe preeclampsia and proteinuria at delivery were correlated with persisting proteinuria at 3 months. Advanced age and higher body mass index were the only determinants of the composite outcome of persisting hypertension or proteinuria at three and six months. CONCLUSION: Hypertension and proteinuria are very common beyond the postpartum period in Cameroonian women with severe preeclampsia and eclampsia. Long-term follow-up of these women will help preventing and controlling related complications.
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Kaze et al. (2014) conducted a cohort in Severe preeclampsia and eclampsia (n=54). Severe preeclampsia and eclampsia was evaluated on Time trend in blood pressure levels, renal function and proteinuria after delivery (p=<0.002). In women with severe preeclampsia and eclampsia, blood pressure, renal function, and proteinuria improved over 6 months postpartum, though hypertension persisted in 14.8%.
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