Key result
Rivaroxaban therapy in an 82-year-old female with non-valvular atrial fibrillation was associated with a fatal acute spontaneous haemopericardium.
Case Report (n=1)
This case highlights a rare but fatal complication of spontaneous haemopericardium associated with rivaroxaban use in an elderly patient with AF and worsening renal function.
May signal rare fatal haemopericardium with rivaroxaban in elderly AF with renal decline; case report leaves open incidence and causality questions.
An 82-year-old female was admitted with chest pain and non-specific T wave changes on her ECG. After 72 hours of conservative management she deteriorated with non-specific symptoms including nausea and a single episode of vomiting. Abdominal and Chest X-rays were unremarkable, blood tests showed worsening Acute Kidney Injury (AKI) on Chronic Kidney Disease (CKD); and raised C-Reactive Protein (CRP) with no obvious symptoms or focus of infection. She rapidly deteriorated going into asystole cardiac arrest and attempts at resuscitation failed. Post-mortem examination suggested the most likely cause of death was acute spontaneous Haemopericardium due to Rivaroxaban therapy which she was on for non-valvular Atrial Fibrillation (AF). We believe that this might be the first reported mortality with Rivaroxaban-associated spontaneous haemopericardium in the UK.
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Omer et al. (2019) conducted a case report in Non-valvular Atrial Fibrillation (n=1). Rivaroxaban was evaluated on Mortality due to acute spontaneous haemopericardium. Rivaroxaban therapy in an 82-year-old female with non-valvular atrial fibrillation was associated with a fatal acute spontaneous haemopericardium.
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