Key result
A solitary diastolic blood pressure J-curve with elevated systolic blood pressure strongly suggests increased large artery stiffness, whereas combined J-curves suggest reverse causality.
Why the study?
Does antihypertensive therapy reduce cardiovascular disease risk without inducing a J-curve of increased risk in older people with isolated systolic hypertension?
Population
Older people with isolated systolic hypertension (ISH)
Design
Review
Authors
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Supports stiffness or reverse causality for isolated diastolic J-curve in ISH; leaves open whether BP lowering safely avoids excess risk in older adults.
Does antihypertensive therapy reduce cardiovascular disease risk without inducing a J-curve of increased risk in older people with isolated systolic hypertension?
The J-curve of cardiovascular risk associated with low diastolic blood pressure in isolated systolic hypertension is more likely a marker of increased arterial stiffness or reverse causality rather than a consequence of treatment-induced ischemia.
Stanley S. Franklin (2010) conducted a review in Isolated systolic hypertension. Blood pressure lowering was evaluated. A solitary diastolic blood pressure J-curve with elevated systolic blood pressure strongly suggests increased large artery stiffness, whereas combined J-curves suggest reverse causality.
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