Key result
Familial erythromelalgia is a channelopathy caused by mutations in the Na(v)1.7 sodium channel, making it the first human disorder linking an ion channel mutation to chronic neuropathic pain.
Identifies familial erythromelalgia as the first human disorder associating an ion channel mutation with chronic neuropathic pain, opening avenues for targeted therapies.
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Supports NaV1.7-targeted investigation in erythromelalgia; leaves open translation to other neuropathic pain syndromes.
Waxman et al. (2005) conducted a review in Familial erythromelalgia. Na(v)1.7 sodium channel mutations was evaluated. Familial erythromelalgia is a channelopathy caused by mutations in the Na(v)1.7 sodium channel, making it the first human disorder linking an ion channel mutation to chronic neuropathic pain.
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