Key result
IV to SC treprostinil transition succeeds in a pediatric patient with PH secondary to ILD.
Why the study?
Treatment strategies for pulmonary hypertension are understudied in pediatric patients, and reports of transitioning from intravenous to subcutaneous treprostinil are lacking.
Is the transition from intravenous to subcutaneous treprostinil successful in a pediatric patient with pulmonary hypertension?
Case Report (n=1)
Is the transition from intravenous to subcutaneous treprostinil successful in a pediatric patient with pulmonary hypertension?
This case report provides initial evidence that transitioning from intravenous to subcutaneous treprostinil can be successful in pediatric patients with pulmonary hypertension.
Hypothesis-generating for IV-to-SC treprostinil transition in pediatric PH; prospective studies required before practice change.
Pulmonary hypertension (PH) causes significant morbidity and mortality in children, and, while the treatment strategies for PH in adults are well studied and developed, few data exist for pediatric patients. In adult patients, successful transitions from intravenous (IV) epoprostenol to subcutaneous (SC) treprostinil are reported, but this information is limited for pediatric patients. Furthermore, while there are reports of SC to IV treprostinil in adults, there are no reports of the transition from IV to SC treprostinil. This case report recounts a successful transition from IV treprostinil to SC treprostinil in a pediatric patient with WHO Class 3, PH, secondary to interstitial lung disease.
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Rockwell et al. (2020) conducted a case report in Pulmonary hypertension (WHO Class 3, secondary to interstitial lung disease) (n=1). Transition from intravenous to subcutaneous treprostinil was evaluated on Successful transition. Transition from intravenous to subcutaneous treprostinil was successfully achieved in a pediatric patient with WHO Class 3 pulmonary hypertension secondary to interstitial lung disease.
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