Key result
Simulated hypogravity using ortho- and antiorthostatic hypokinesia significantly increased diastolic blood pressure variability and its LF component by day 21 compared to milder conditions.
Why the study?
What are the most informative cardiovascular parameters for assessing the physiological effects of simulated hypogravity?
What are the most informative cardiovascular parameters for assessing the physiological effects of simulated hypogravity?
Blood pressure variability indexes, particularly diastolic BP variability, are highly sensitive parameters for assessing cardiovascular changes during simulated hypogravity.
Diastolic BP variability may serve as a sensitive marker in simulated hypogravity; hypothesis-generating for space physiology monitoring.
Changes in cardiovascular system (CVS) under conditions of hypogravity simulated using 7- and 21-day ortho- and antiorthostatic hypokinesia at different angles were studied. The aim of the experiment was selection of informative CVS parameters most sensitive to these conditions. Simultaneous recording of 26 CVS parameters on a spiroartheriocardiorythmograph showed that the most sensitive parameters were blood pressure (BP) variability indexes in functional tests: differences in groups with varying degrees of orthostatic hypokinesia (+ 9.6˚ and + 15˚) were observed starting from the first week of the experiment. By day 21, pronounced changes in the total spectral power of diastolic BP variability were noted in the group exposed to constant antiorthostasis. This parameter significantly surpassed the corresponding value in the groups with milder conditions. Significant increase in the LF component of diastolic BP in groups exposed to severe antiorthostasis and orthostasis was detected. Presumably, autonomic mechanisms affecting the systolic and diastolic BP under conditions of hypogravity simulation are different, at least partially.
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А. Б. Черепов (2015) studied Hypogravity. Ortho- and antiorthostatic hypokinesia vs. Milder conditions was evaluated on Blood pressure variability indexes. Simulated hypogravity using ortho- and antiorthostatic hypokinesia significantly increased diastolic blood pressure variability and its LF component by day 21 compared to milder conditions.
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