Why the study?
Does acute hypovolemia augment the sympathoneural and vasomotor response to graded orthostatic stress in humans?
Population
8 human subjects
Comparison
Spironolactone 100 mg/day for 3 days vs Placebo (normovolemia condition)
Design
RCT, Randomly assigned placebo or diuretic
Follow-up
3 days
Authors
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Acute hypovolemia enhances orthostatic BP stability via neurovascular augmentation; extends microgravity research with direct RCT evidence in humans.
Does acute hypovolemia augment the sympathoneural and vasomotor response to graded orthostatic stress in humans?
Acute hypovolemia augments neurovascular responses to orthostatic stress, compensating for reduced stroke volume and cardiac output.
Kimmerly et al. (2002) studied this question.
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