Library of 2‐(isoxazol‐3‐yl)‐1 H ‐imidazole sulfonamide derivatives (4 a‐j) has been synthesized and structures were confirmed by 1 HNMR, 13 CNMR and mass spectral analysis. Further these compounds were tested for their anticancer activity against four human cancer cell lines, such as MCF‐7 (breast cancer), A549 (lung cancer), Colo‐205 (colon cancer) and A2780 (ovarian cancer) by MTT assay and etoposide used as positive control. Among them, compounds 4 b , 4 c , 4 d , 4 e , 4 g , 4 h and 4 i showed more potent anticancer activity against human cancer cell lines.
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Dende et al. (2020) studied this question.
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