Structural elucidation of HIV-1 G-quadruplexes in a cellular environment and their ligand binding using responsive 19 F-labeled nucleoside probes

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DNA polymerase stop assay, we monitored GQ- and hairpin-specific ligand interactions and their synergistic inhibitory effect on the replication process. Our findings suggest that targeting GQ and hairpin motifs simultaneously using bimodal ligands could be a new strategy to selectively block the viral replication.