Key result
Women with peripheral artery disease had lower 6-minute walk test distance (P<0.001) and higher pulse pressure (P=0.002) and augmentation index (P<0.001) compared with men.
Why the study?
Functional and cardiovascular variables had not been adequately compared between men and women with peripheral artery disease.
Do functional and cardiovascular variables differ between men and women with peripheral artery disease?
Cross-Sectional (n=211)
Do functional and cardiovascular variables differ between men and women with peripheral artery disease?
p-value: p=<0.001
Women with peripheral artery disease exhibit higher blood pressure and wave reflection variables compared to men, highlighting the need for targeted interventions in this group.
May warrant sex-specific functional assessment in PAD; leaves open whether targeted interventions improve outcomes.
PURPOSE: To compare functional and cardiovascular variables of men and women with peripheral artery disease (PAD). METHODS: This observational, cross-sectional study included 67 women and 144 men (age 66 ± 9 and 67 ± 10 yr, respectively) with PAD. Patients were submitted to a clinical evaluation, 6-min walk test (6MWT) and cardiovascular evaluation, including blood pressure, arterial stiffness variables, and heart rate variability. RESULTS: Women had lower claudication onset distance (P = .033) and 6MWT distance (P < .001), and similar percentage of the predicted 6MWT distance (P > .05). Women had higher pulse pressure (P = .002), augmentation index (P < .001), augmentation index corrected by 75 bpm (P < .001), and brachial and central systolic blood pressure (P = .041 and P = .029). Diastolic blood pressure, pulse wave velocity, and heart rate variability were similar between sexes (P > .05). CONCLUSION: Although predicted 6MWT performance was similar between sexes, women had higher blood pressure and wave reflection variables compared with men. Interventions to reduce blood pressure and wave reflection should be emphasized in women with PAD.
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Correia et al. (2019) conducted a cross-sectional in Peripheral artery disease (PAD) (n=211). Female sex vs. Male sex was evaluated on Functional and cardiovascular variables (including 6-minute walk test distance, pulse pressure, and augmentation index) (p=<0.001). Women with peripheral artery disease had lower 6-minute walk test distance (P<0.001) and higher pulse pressure (P=0.002) and augmentation index (P<0.001) compared with men.
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