F-14 | Sex Comparison in Peripheral Artery Disease: Unveiling the Asymptomatic Profile in Women

This study aimed to evaluate the prevalence of Peripheral Artery Disease (PAD) based on sex by analyzing a multinational database. Data from the Trinetx database spanning January 1st, 2015, to October 1st, 2023, were examined, identifying 1,189,435 PAD cases, categorized into male (n=585,005) and female (n=604,430) groups. To address group disparities, a 1:1 propensity match was conducted, resulting in 526,227 matched pairs. The study controlled for cardiology and vascular comorbidities. Findings indicate a lower mortality rate from PAD in females (6.4%) compared to males (7.7%, P<0.001) within a one-year timeframe. Additionally, amputation rates were higher in males (2.6% vs. 1.3%, P<0.001), as were incidences of Acute Myocardial Infarction (AMI) (7.3% vs. 5.2%, P<0.001). These results underscore the necessity of PAD screening for both sexes. While male sex has been traditionally viewed as a significant risk factor for vascular diseases, our study highlights the need for gender-specific research to enhance the diagnosis of women with asymptomatic vascular conditions. This approach is crucial in developing tailored interventions and improving health outcomes across both genders.