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Phenylpyruvic acid was demonstrated in the blood of 39 patients affected with phenylpyruvic oligophrenia. The values ranged from 0.31 to 1.78 mg per 100 ml of plasma. A significant increase of phenylketonemia was observed following ingestion of DL-phenylalanine, the D form causing considerably greater increase than the L isomer. Feeding of phenylpyruvic acid resulted in a sharp increase of phenylketonemia. The significance of these findings is briefly discussed.
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George A. Jervis (1952) studied this question.
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