Metabolites of phencyclidine in humans

A N-dealkylated metabolite, 1-phenylcyclohexylamine, was detected in a urine sample of a patient who had ingested phencyclidine. The identification was facilitated by a feeding experiment using a mouse administered a 1:1 mixture of unlabeled and phenyl-d5-labeled drug. A control experiment was also performed in which a mouse was fed only the unlabeled drug. Two hydroxylated metabolities were also identified in human urine samples. One of the hydroxylated metabolites has a hydroxy group located at the piperidine moiety of phencyclidine while the other has the hydroxy group located at the cyclohexane ring of the drug. It was also shown that 1-phenyl-cyclohexene detected in the human samples, was an artifact which arose from pyrolysis of phencyclidine during gas chromatography.