This is the authors' abstract. We don't add key points for this paper.
[formula: see text] The synthesis of thrombin inhibitor 3, which incorporates conformationally constrained 7-azabicycloheptane carboxylic acid (1) as a proline replacement, is described. The inhibition constant (Ki(thrombin) = 2.9 nM) indicates that 1 is a reasonable replacement of proline in the formation of a beta-turn tripeptide mimetic.
Answers are grounded in this paper and cite their sources.
No takes yet. Share an insight, caveat, or question.
Han et al. (1999) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: