Key result
Temporally controlled overexpression of cardiac PI3Kalpha in adult mice for 2 weeks increased myocardial contractility without inducing hypertrophy or cardiomyopathy.
Temporally controlled overexpression of cardiac PI3Kalpha in adult mice enhances myocardial contractility without inducing hypertrophy, highlighting a distinct phenotype from prolonged constitutive activation.
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Short-term PI3Kalpha activation may enhance contractility; leaves open translation to human HF therapies.
Yano et al. (2008) studied this question. Temporally controlled overexpression of cardiac-specific PI3Kalpha was evaluated on Cardiac contractility (LV developed pressure and dP/dt). Temporally controlled overexpression of cardiac PI3Kalpha in adult mice for 2 weeks increased myocardial contractility without inducing hypertrophy or cardiomyopathy.
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