Key result
Surgical resection of an isolated liver metastasis from an extremity myxoid/round cell liposarcoma was successfully performed, but the patient experienced disease progression outside the liver 5 months later.
Case Report (n=1)
Complete resection of isolated liver metastasis from extremity liposarcoma is the best chance for cure, but recurrence outside the liver is common and rapid.
Resection of isolated liver metastasis in extremity myxoid liposarcoma may be feasible; leaves open durability of benefit given rapid extrahepatic progression in this case.
BACKGROUND: Extremity liposarcomas can metastasize to different areas of the body but have rarely been demonstrated to metastasize to the liver. Due to the unusual occurrence of isolated metastatic extremity liposarcoma to the liver, the optimal treatment of this condition is unknown. CASE PRESENTATION: Less than one year after resection of a myxoid/round cell liposarcoma of the left lateral calf, a 61-year-old male presented with a CT scan showing a 2 cm low-density lesion in the right lobe of the liver. The lesion tripled in size over the next few months. An extensive evaluation revealed isolated disease to the liver. The lesion was surgically removed with a right hepatic lobectomy and the pathology was consistent with metastatic myxoid/round cell liposarcoma. CONCLUSION: Although extremity liposarcoma rarely metastasizes solely to the liver, the best chance at cure is with complete resection. Unfortunately, cure rates are very low in the setting of metastatic disease. As expected, the patient experienced progression of disease at sites outside of the liver 5 months after the liver resection.
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Garces et al. (2008) conducted a case report in Isolated metastatic extremity liposarcoma to the liver (n=1). Right hepatic lobectomy was evaluated on Disease progression. Surgical resection of an isolated liver metastasis from an extremity myxoid/round cell liposarcoma was successfully performed, but the patient experienced disease progression outside the liver 5 months later.
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